Targeted Orexin and Hypothalamic Neuropeptides for Migraine

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Migraine and neuropeptides.

Migraine is a common disabling neurovascular primary headache disorder. The pathomechanism is not clear, but extensive preclinical and clinical studies are ongoing. The structural basis of the leading hypothesis is the trigeminovascular system, which includes the trigeminal ganglion, the meningeal vasculature, and the distinct nuclei of the brainstem, the thalamus and the somatosensory cortex. ...

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Orexin depolarizes rat hypothalamic paraventricular nucleus neurons.

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ژورنال

عنوان ژورنال: Neurotherapeutics

سال: 2018

ISSN: 1933-7213,1878-7479

DOI: 10.1007/s13311-017-0602-3